Recombinant Human TWEAK Receptor/TNFRSF12A
產品編號
產品名稱
產品包裝
產品價格
XY385-1mg
1mg
15444.00元
Species
Gene ID
Accession
Source
Length
MW
Tag
Human
51330
Q9NP84
E. coli
53aa
5.6kDa
－
About this Antibody
Name
Recombinant Human TWEAK Receptor/TNFRSF12A (Recombinant Human TNF-related Weak Inducer of Apoptosis Receptor; rHuTWEAK Receptor)；重組人腫瘤壞死因子相關的弱受體細胞凋亡的誘導/TNFRSF12A
Synonyms
CD266; Fn14; TNFRSF12; TNFRSF12A; CD266; CD266 antigen; FGF-inducible 14; Fibroblast growth factor-inducible immediate-early response protein 14; FN14tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; TWEAKR; TweakR; tweak-receptor; Tweak-receptor; type I transmembrane protein Fn14
Purity
>95% by SDS-PAGE and HPLC analyses.
Biological Activity
Fully biologically active when compared to standard. The ED50 as determined by inhibiting TWEAKdependent proliferation of human umbilical vein endothelial cells (HUVEC) is less than 30ng/ml, corresponding to a specific activity of >3.3×104IU/mg, in the presence of 15ng/ml of rHuTWEAK.
Physical Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH7.4.
Endotoxin
Less than 1EU/μg of rHuTWEAK Receptor as determined by LAL method.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.
Category
Cytokine
Background
Human TNF-related weak inducer of apoptosis receptor (TWEAKR) also known as Tumor necrosis factor receptor superfamily member 12A precursor (gene name TNFRSF12A) or fibroblast growth factor-inducable 14kDa protein, is distantly related to the TNFR family, containing one cysteine-rich domain in the extracellular region and a TNFR-associated factor binding domain but does not contain a death domain (DD) cytoplasmic region. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAK receptor can be activated by either the membrane anchored or the soluble TWEAK. In addition, It plays a role in TWEAK-induced endothelial cell migration, proliferation, and angiogenesis. Human and mouse TWEAK R share 82%a.a. sequence identity.
Amino Acid Sequence
EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP
包裝清單:
包裝
XY385-5μg
5μg
XY385-25μg
25μg
XY385-100μg
100μg
-
說明書
1份
保存條件: -20℃或更低溫度保存，至少一年有效。由于蛋白的每次凍融均會引起部分失活，所以**配制成相應濃度的儲存液后(請根據產品簡介中Reconstitution一欄的信息配制儲存液)，須分裝后-20℃或更低溫度凍存，以避免反復凍融。 注意事項: 由于有些塑料管壁對某些蛋白有較強的吸附作用，溶液中的蛋白很容易粘附在管壁上，并且粘附后的蛋白很難與管壁分離。而載體蛋白(Carrier protein，如0.1% BSA等)的主要作用是預先封閉塑料管壁上的蛋白結合位點，使細胞因子或重組蛋白不會粘附于管壁。所以一定要使用產品簡介中Reconstitution一欄的信息配制儲存液。 本產品**于專業人員的科學研究用，不得用于臨床診斷或**，不得用于食品或藥品，不得存放于普通住宅內。 為了您的**和健康，請穿實驗服并戴一次性手套操作。